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Antibiotic susceptibility of Streptococcus pneumoniae isolated from clinical materials (author's transl)
Abstract:
We tested the drug-susceptibility of 112 strains of Streptococcus pneumoniae isolated from various clinical materials since January 1975 to May 1976, and observed the changes of susceptibility of this pathogen. All strains tested remained very sensitive to benzylpenicillin and cephaloridine, but 59.8% of strains were resistant to tetracycline and 44.7% to chloramphenicol, and about 90% of chloramphenicol-resistant strains were also resistant to tetracycline. The percentage of resistant strains to tetracycline or chloramphenicol is increasing. Cross-resistance between tetracycline and doxycycline or chloramphenicol and thiamphenicol was observed. On this time we found three strains resistant to macrolides. Two of these strains were resistant to erythromycin, josamycin, oleandomycin, spiarmycin, mydecamycin, lincomycin, clindamycin and tetracycline, but one was resistant to josamycin, spiramycin, mydecamycin and chloramphenicol.
Insights
Drug resistance in Streptococcus pneumoniae is increasing, particularly to tetracycline and chloramphenicol. Few strains showed macrolide resistance, with some exhibiting cross-resistance to other antibiotics.
Area of Science:
- Microbiology
- Infectious Diseases
- Pharmacology
Context:
- Analysis of drug susceptibility patterns in Streptococcus pneumoniae strains.
- Clinical isolates collected between January 1975 and May 1976.
- Monitoring antimicrobial resistance trends in a key bacterial pathogen.
Purpose:
- To assess the drug-susceptibility of Streptococcus pneumoniae isolates.
- To identify emerging resistance patterns to common antibiotics.
- To observe changes in the susceptibility profile of this pathogen over time.
Summary:
- 112 Streptococcus pneumoniae strains showed consistent sensitivity to benzylpenicillin and cephaloridine.
- High resistance rates were observed for tetracycline (59.8%) and chloramphenicol (44.7%).
- Significant cross-resistance was noted between tetracycline and doxycycline, and chloramphenicol and thiamphenicol. Three strains displayed macrolide resistance, with varying cross-resistance profiles.
Impact:
- Highlights the growing challenge of antibiotic resistance in Streptococcus pneumoniae.
- Informs clinical decision-making regarding antibiotic selection for pneumococcal infections.
- Provides baseline data for future surveillance of antimicrobial resistance trends.