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Updated: Aug 12, 2026

Evaluation of the Efficacy And Toxicity of RNAs Targeting HIV-1 Production for Use in Gene or Drug Therapy
Published on: September 5, 2016
Gene therapy progress and prospects: viral trafficking during infection
1Department of Microbiology and Immunology, University of Illinois at Chicago, 835 S. Wolcott Rm. E-703, Chicago, IL 60612, USA.
Abstract:
The intracellular steps involved in viral infection, namely cytoplasmic trafficking and nuclear import, are critical events in the viral life cycle that have lagged behind other areas of viral research. This review examines recent advances in our understanding of these steps for viruses commonly employed as viral gene delivery vectors. Steps governing the cytoplasmic trafficking and nuclear import of Herpes Simplex virus, Human Immunodeficiency virus and Adenovirus are reviewed in this article.
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