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Related Experiment Videos

Apoptosis, proliferation and gene expression patterns in mouse developing tongue.

Xuguang Nie1

  • 1Section of Anatomy and Cell Biology, Department of Biomedicine, University of Bergen, Jonas Lies V91, 5009, Bergen, Norway. Xuguang.Nie@biomed.uib.no

Anatomy and Embryology
|September 10, 2005
PubMed
Summary

Fibroblast Growth Factor (Fgf) and Bone Morphogenetic Protein (Bmp) signaling pathways are crucial for embryonic development, including tongue formation. This study maps their expression and roles in mouse tongue development, revealing key insights into growth regulation.

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Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Genetics

Background:

  • Fibroblast Growth Factor (Fgf) and Bone Morphogenetic Protein (Bmp) signaling pathways are essential for embryonic development and postnatal growth.
  • Understanding these pathways' roles in tongue development is crucial for comprehending craniofacial morphogenesis.

Purpose of the Study:

  • To investigate the expression patterns of key Fgf/Fgfr and Bmp pathway members during mouse tongue development.
  • To analyze the roles of apoptosis and proliferation in tongue morphogenesis.
  • To elucidate the spatiotemporal regulation of tongue development by these signaling pathways.

Main Methods:

  • Expression pattern analysis of Fgf, Fgfr, and Bmp family members in developing mouse tongues using immunohistochemistry or in situ hybridization.

Related Experiment Videos

  • Assessment of cell proliferation and apoptosis during embryonic and postnatal tongue development.
  • Correlation of signaling molecule expression with developmental stages and cellular processes.

    • Main Results:

    • Proliferation is vigorous in early tongue development, while apoptosis is a late event restricted to the epithelium.
    • Bmp2, -4, -5 are expressed in the mesenchyme, and Bmp3, -7 in the epithelium during early development (E12-E13).
    • Fgfr1c, -2b, -2c show peak expression at E11-E13, with specific mesenchymal and epithelial localizations.
    • Fgf7 and Fgf10 are highly expressed in the mesenchyme, correlating with Fgfr expression, suggesting a key role in early tongue expansion.
    • Fgf2 is detected in tongue muscles during late embryonic and postnatal stages.

    Conclusions:

    • Bmp and Fgf signaling pathways regulate mouse tongue development at multiple embryonic and postnatal stages.
    • These pathways likely influence tongue development through modulation of cell proliferation and differentiation.
    • The findings provide a foundation for understanding the molecular mechanisms underlying normal and abnormal tongue development.