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[Cations in the human blood serum]
Uspekhi Fiziologicheskikh Nauk
|September 13, 2005
Summary
Human serum cation concentrations (Na+, K+, Ca2+, Mg2+) and osmolality remain stable throughout life. Regulatory systems maintain these vital parameters within normal limits across various physiological and pathological states.
Area of Science:
- Biochemistry
- Human Physiology
- Clinical Chemistry
Context:
- Human serum analysis is crucial for understanding physiological homeostasis.
- Physiological and pathological states significantly impact body fluid composition.
- Physiologically active substances can alter blood serum parameters.
Purpose:
- To review and synthesize data on human serum cation concentrations and osmolality.
- To establish mean values for serum osmolality and cation levels in healthy individuals.
- To identify states associated with deviations in physicochemical parameters of bodily fluids.
Summary:
- This review consolidates data from over 450 references and thousands of measurements on serum cations (Na+, K+, Ca2+, Mg2+) and osmolality.
- Mean values for healthy individuals were calculated, revealing remarkable stability from birth throughout life.
- The body's regulatory systems effectively maintain these parameters within normal ranges, even during various physiological and pathological conditions.
Impact:
- Provides a comprehensive reference for normal ranges of key serum electrolytes and osmolality.
- Highlights the robustness of physiological regulatory mechanisms in maintaining homeostasis.
- Aids in the interpretation of clinical chemistry results and the diagnosis of related disorders.