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Updated: Aug 16, 2026

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Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice
Published on: May 16, 2019
Functional GABA uptake at inhibitory synapses in CA1 of chronically epileptic rats
Frank Stief1, Antje Piechotta, Sigrun Gabriel
1Neurowissenschaftliches Forschungszentrum der Charité, Schumannstr. 20/21, 10117 Berlin, Germany.
Epilepsy Research
|September 13, 2005
Abstract:
Inhibitory postsynaptic currents were measured in CA1 pyramidal cells from chronically epileptic rats (pilocarpine model). Tiagabine, a selective inhibitor of the GABA-uptake transporter 1 prolonged currents equally to cells from control animals. Thus, GABA-uptake has an unaltered impact on inhibitory synaptic efficacy in rats with chronic temporal lobe epilepsy, underlining the rational for the use of GABA-uptake blockers in this condition.

