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[Interleukin-1 polymorphisms in patients with aggressive periodontitis].
Qi-yan Li1, Hong-shan Zhao, Huan-xin Meng
1Department of Periodontology, School of Stomatology, Peking University, Beijing 100081, China.
Shanghai Kou Qiang Yi Xue = Shanghai Journal of Stomatology
|September 13, 2005
Summary
Genetic variations in interleukin-1 (IL-1) may influence aggressive periodontitis (AgP) risk. Specifically, IL-1A +4845 polymorphism is linked to AgP susceptibility in Chinese males.
Area of Science:
- Genetics
- Periodontology
- Immunology
Background:
- Aggressive periodontitis (AgP) is a severe gum disease.
- Interleukin-1 (IL-1) plays a role in inflammation and immune response.
- Genetic factors may contribute to AgP development.
Purpose of the Study:
- To investigate the association between interleukin-1 (IL-1) genotypes/alleles and aggressive periodontitis (AgP).
Main Methods:
- Genomic DNA was analyzed from 122 AgP patients and 95 healthy controls.
- Polymorphisms in IL-1A, IL-1B, and IL-1RN were genotyped using PCR-RFLP and PCR.
- Logistic regression analyzed genotype and allele distribution differences.
Main Results:
- The IL-1A +4845 A2+ genotype and allele 2 were significantly more frequent in male AgP patients than male controls.
- Adjusted odds ratios indicated increased risk for AgP associated with these IL-1A variants in males.
Conclusions:
- The IL-1A +4845 polymorphism may be associated with increased susceptibility to aggressive periodontitis in Chinese males.