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Inducing Apical Periodontitis in Mice
Published on: August 6, 2019
Osteolectin/CLEC11A-Related Signaling Molecules in Periodontitis and Peri-Implantitis
Gözde Işıker Kara1, Feyzanur Caldiran2,3, Hatice Balci Yuce1
1Department of Periodontology, Faculty of Dentistry, Tokat Gaziosmanpaşa University, Tokat, Turkey.
Oral Diseases
|July 16, 2026
Summary
Osteolectin (CLEC11A) and related signaling molecules show different expression patterns in periodontal health versus periodontitis and peri-implant health versus peri-implantitis. These findings suggest distinct molecular responses in inflammatory conditions affecting teeth and implants.
Area of Science:
- Oral biology
- Periodontology
- Biomaterials science
Background:
- Periodontal and peri-implant tissues exhibit distinct histological and biomechanical properties.
- These differences may influence local osteogenic and mechanosensitive signaling pathways.
- Understanding these signaling differences is crucial for managing periodontal and peri-implant health.
Purpose of the Study:
- To compare the expression profiles of Osteolectin (CLEC11A) and associated signaling molecules.
- To investigate these profiles across conditions of periodontal health, peri-implant health, periodontitis, and peri-implantitis.
- To explore potential differences in osteogenic and mechanosensitive signaling between periodontal and peri-implant tissues.
Main Methods:
- Cross-sectional study involving four groups: Periodontal Health (PH), Peri-Implant Health (PIH), Periodontitis (P), and Peri-Implantitis (PID).
- Quantification of CLEC11A, ITGA11, GSK-3β, and PIEZO1 in gingival/peri-implant crevicular fluids (GCF/PICF) via ELISA.
- Assessment of CLEC11A, ITGA11, GSK-3β, β-catenin, RUNX2, and PIEZO1 tissue expression using qRT-PCR.
Main Results:
- Significantly higher GCF/PICF CLEC11A and ITGA11 levels were observed in Periodontitis (P) and Peri-Implantitis (PID) compared to Periodontal Health (PH).
- β-catenin expression was significantly higher in PIH and P than in PH.
- RUNX2 expression was significantly elevated in PIH, P, and PID versus PH, while PIEZO1 expression was higher in P than PIH.
Conclusions:
- CLEC11A-related signaling appears to be differentially associated with periodontal and peri-implant inflammatory conditions.
- The study highlights distinct molecular signaling responses in inflammatory states affecting teeth versus implants.
- Further research is warranted to elucidate the precise roles of these molecules in tissue health and disease.
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