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Updated: Aug 16, 2026
The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
Published on: February 21, 2025
[The effects of recombinant human growth hormone on mandibular bone loss with or without teeth in the ovariectomized
Xu-xia Wang1, Jun Zhang, Zuo-Qin Zhao
1School of Stomatology, Shandong University, Jinan 250012, Shandong Province, China.
Purpose:
To investigate the effects of recombinant human growth hormone(rh-GH )on mandibular bone loss with or without teeth in the ovariectomized rats.
Methods:
Three-month aged ovariectomized rats were utilized as postmenopausal osteoporosis models and all the molars in left mandibles were extracted. After operations, the rats began to receive rh-GH 1 mg.kg(-1).d(-1) with subcutaneous injection for ten days. Weight of the rats ,mineral density of the mandibular bone and 3 other parameters were measured at 8th week and 12th week. The data was analyzed with F and t test.
Results:
The weight of the rats increased and mandibular bone mineral density of the rats were significantly improved after rh-GH treatment, P<0.05.
Conclusion:
Rh-GH can increase the weight of the old rats and restore mandibular bone mass in mandibles with or without teeth.
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