Related Experiment Videos
Antibiotic prophylaxis following lower urinary tract instrumentation
N N Bhatia1, M M Karram, A Bergman
1Division of Gynecologic Urology, Harbor-UCLA Medical Center.
Urology
|June 1, 1992
Summary
Routine antibiotic prophylaxis significantly reduces urinary tract infections after lower urinary tract instrumentation. Cefadroxil demonstrated comparable efficacy to nitrofurantoin with fewer side effects and simpler dosing.
Area of Science:
- Urology
- Infectious Diseases
- Pharmacology
Background:
- Urinary tract infections (UTIs) are a common complication following lower urinary tract instrumentation.
- Antibiotic prophylaxis is often considered to prevent these infections, but optimal regimens require evaluation.
Purpose of the Study:
- To compare the efficacy and safety of cefadroxil versus nitrofurantoin for antibiotic prophylaxis in women undergoing lower urinary tract instrumentation.
- To assess the effectiveness of these antibiotics against placebo in preventing post-instrumentation UTIs.
Main Methods:
- A randomized, investigator-blinded, placebo-controlled study involving 362 women.
- Participants received a three-day course of either cefadroxil (1g once daily) or nitrofurantoin (100mg three times daily), or placebo.
Main Results:
- Both cefadroxil and nitrofurantoin were significantly more effective than placebo in preventing post-instrumentation UTIs (p < 0.003).
- No significant difference in efficacy was observed between cefadroxil and nitrofurantoin.
- Nitrofurantoin was associated with more frequent and severe side effects compared to cefadroxil.
Conclusions:
- Cefadroxil and nitrofurantoin are effective prophylactic agents against UTIs after lower urinary tract instrumentation.
- Cefadroxil offers a favorable safety profile and a convenient once-daily dosing schedule, making it a potentially preferred option.