Related Experiment Video
Updated: Aug 16, 2026

Basophil Activation Test for Allergy Diagnosis
Published on: May 31, 2021
[Therapeutic options in idiopathic chronic urticaria]
Patricia Montero Mora1, Maria del Carmen González Pérez, Margarita Jiménez Villarruel
1Servicio de alergia e inmunología clinica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, IMSS.
Background:
Chronic idiopathic urticaria is a clinic entity that is manifested by wheals of more than six weeks of evolution, without identification of the causing agent, and sometimes resistant to conventional treatment. There are improvements with leukotriene receptor antagonists.
Objective:
To evaluate the clinical efficacy of montelukast and desloratadine individually and combined, compared with hydroxicine.
Patients And Methods:
The trial included 40 subjects with chronic idiopathic urticaria referred from the outpatient allergy service. They were randomly divided into four groups to receive: hydoxicine, montelukast, montelukast plus desloratadine, and desloratadine alone during six weeks. The assessments compared the first and sixth weeks.
Results:
All therapeutic options are effective, with statistical significance, highlighting that the new therapeutic modes are safe and have better resolution of lesions and symptoms.
Conclusions:
All the alternatives are viable, considering they are adjusted to each patient, adverse symptoms, socio-economic status and clinical severity.
Related Concept Videos
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...
Hypersensitivity Reactions: Cytolytic Reactions
Antiasthma Drugs: Leukotriene Modifiers
Leukotriene modifiers work through two distinct mechanisms:
Peptic Ulcer Disease IV: Management
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current medication...
Drug Toxicity: Allergic Reactions