Hemoglobin-based hydrogen peroxide biosensor tuned by the photovoltaic effect of nano titanium dioxide

The photovoltaic effect of titanium dioxide (TiO2) nanoparticles, induced by ultraviolet light, can greatly improve the catalytic activity of hemoglobin as a peroxidase, with the sensitivity increased nearly 3-fold and the detection limit lowered 2 orders, in contrast to the catalytic reactions in the dark, which indicates a possible method to tune the properties of proteins for development of photocontrolled protein-based biosensors.