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Updated: Jul 13, 2026

State-Dependency Effects on TMS: A Look at Motive Phosphene Behavior
Published on: December 28, 2010
Excited state enantiodifferentiating interactions between a chiral benzophenone derivative and nucleosides
Virginie Lhiaubet-Vallet1, Susana Encinas, Miguel A Miranda
1Instituto de Tecnología Química UPV-CSIC, Universidad Politécnica de Valencia, Avda de Los Naranjos s/n, 46022 Valencia, Spain.
Abstract:
Time-resolved measurements using nanosecond laser flash photolysis have revealed significant enantiodifferentiation in the interaction between ketoprofen (a chiral benzophenone derivative) and two relevant nucleosides, namely, thymidine and 2'-deoxyguanosine. In both cases, the highest quenching rate constants have been observed for (R)-ketoprofen, the enantiomer with lower pharmacological activity. Photoproduct studies performed in the case of thymidine suggest that the enantiodifferentiating process corresponds to a Paterno-Büchi reaction, leading to the formation of oxetanes. With 2'-deoxyguanosine, the quenching is associated with an electron-transfer process monitored through the generation of a ketyl radical.
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