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Serratia corneal ulcers: a retrospective clinical study
Jeane Haidee Mah-Sadorra1, Dany M Najjar, Christopher J Rapuano
1Cornea Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Cornea
|September 15, 2005
Summary
Serratia marcescens keratitis often affects those with abnormal corneas or who use topical medications and contact lenses. Prompt treatment leads to favorable outcomes in most cases.
Area of Science:
- Ophthalmology
- Microbiology
- Infectious Diseases
Background:
- Serratia marcescens is a Gram-negative bacterium that can cause opportunistic infections.
- Corneal ulcers are a serious condition that can lead to vision loss.
- Understanding the risk factors and treatment outcomes for Serratia keratitis is crucial for effective patient management.
Purpose of the Study:
- To investigate the clinical features and microbiological characteristics of Serratia corneal ulcers.
- To identify associated risk factors and treatment responses in patients with Serratia keratitis.
Main Methods:
- A retrospective, observational case series design was employed.
- Clinical records of patients diagnosed with Serratia marcescens corneal ulcers between 1998 and 2002 were reviewed.
- Data collected included patient demographics, clinical presentation, microbiological findings, treatment, and outcomes.
Main Results:
- Twenty-four cases of Serratia keratitis were identified in 21 patients.
- A majority of infections (71%) were linked to an abnormal corneal surface, with 57% occurring in corneal grafts.
- Topical medication use (corticosteroids, antiglaucoma drops) and contact lens wear were significant risk factors.
Conclusions:
- Serratia marcescens keratitis is frequently associated with pre-existing corneal abnormalities, topical medication use, and contact lens wear.
- Early and appropriate medical intervention generally leads to a positive clinical outcome for most patients.