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The ontogeny of biochemical markers of cardiac dysfunction

James C Huhta1, Alfred Asante-Korang, Maria Serrano

  • 1Department of Pediatrics, University of South Florida, Tampa, Florida 33701, USA. huhfam@aol.com

Current Opinion in Pediatrics
|September 15, 2005
PubMed

Insights

Biochemical markers like natriuretic peptides and cardiac enzymes signal heart strain in pediatric patients. Early detection aids in diagnosing cardiac involvement and maladaptation during development.

Area of Science:

  • Biochemistry
  • Pediatric Cardiology
  • Developmental Biology

Background:

  • Cardiac involvement is a concern in various pediatric diseases.
  • Biochemical markers can indicate cardiac stress and maladaptation.
  • Understanding these markers' expression across development is crucial.

Purpose of the Study:

  • To review biochemical markers for detecting cardiac involvement in pediatric disease.
  • To summarize markers identified in fetal and pediatric practice.
  • To trace marker expression from embryonic development through adulthood.

Main Methods:

  • Review of scientific literature on biochemical markers in pediatric cardiology.
  • Analysis of available diagnostic markers in clinical laboratories.
  • Tracing the developmental expression of cardiac markers.

Main Results:

  • Three key biochemical markers are readily available for improved diagnosis.
  • Increased cardiac workload triggers the release of natriuretic peptides and cardiac enzymes.
  • These markers indicate activated genetic programs and maladaptation in the heart.

Conclusions:

  • Biochemical markers are valuable tools for detecting cardiac involvement in pediatric conditions.
  • The expression of these markers changes throughout development, offering insights into cardiac health.
  • Consideration of these markers is recommended for comprehensive pediatric cardiac assessment.
Abstract

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