Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Synaptonemal complex formation: where does it start?

Kiersten A Henderson1, Scott Keeney

  • 1Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA. s-keeney@ski.mskcc.org

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|September 16, 2005
PubMed
Summary

The synaptonemal complex protein Zip1 plays a key role in linking meiotic recombination and centromere pairing in budding yeast. This discovery offers new insights into the formation and function of the synaptonemal complex during meiosis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A multi-species toolkit of TOP2 hypercleavage mutants for studying topoisomerase II-mediated DNA damage.

bioRxiv : the preprint server for biology·2026
Same author

MRE11 suppresses germline mutagenesis at meiotic double-strand breaks in mice.

bioRxiv : the preprint server for biology·2026
Same author

A regulatory role of novel long non-coding RNA, BAZ1A-AS1, in vascular smooth muscle cell functions during neointima formation in human saphenous veins.

bioRxiv : the preprint server for biology·2026
Same author

Structure-informed evolutionary analysis of the meiotic recombination machinery.

bioRxiv : the preprint server for biology·2025
Same author

TRIP13 fosters both transcriptional silencing and DSB repair during meiosis.

bioRxiv : the preprint server for biology·2025
Same author

Insight into meiotic DNA end resection: Mechanisms and regulation.

DNA repair·2025

Area of Science:

  • Cell Biology
  • Genetics
  • Molecular Biology

Background:

  • The synaptonemal complex is a crucial structure in meiosis, essential for proper chromosome segregation.
  • Its assembly is tightly regulated and linked to the process of meiotic recombination.

Purpose of the Study:

  • To investigate the function of the synaptonemal complex protein Zip1.
  • To explore the relationship between synaptonemal complex assembly and centromere pairing during meiotic prophase.

Main Methods:

  • Utilized budding yeast as a model organism.
  • Analyzed the role of the Zip1 protein in centromere pairing and synaptonemal complex formation.

Main Results:

  • Identified an unexpected role for Zip1 in facilitating centromere pairing.

Related Experiment Videos

  • Demonstrated a direct link between a synaptonemal complex component and centromere association.

    • Conclusions:

    • Zip1's function extends beyond its known role in synaptonemal complex structure.
    • These findings provide novel insights into the mechanisms governing chromosome pairing and synaptonemal complex assembly in meiosis.