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Allelic isoforms and decrease in serotonin transporter mRNA in lymphocytes of patients with major depression.

L Lima1, S Mata, M Urbina

  • 1Laboratorio de Neuroquímica, Centro de Biofísica y Bioquímica, Instituto Venezolano de Investigaciones Científicas, Caracas, Venezuela.

Neuroimmunomodulation
|September 17, 2005
PubMed
Summary

Major depression is linked to reduced serotonin transporter mRNA and fewer cells expressing it in lymphocytes. This suggests nervous-immune interactions may play a role in depression.

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Area of Science:

  • Neuroscience
  • Immunology
  • Genetics

Background:

  • Reduced serotonin transporter (SERT) binding in lymphocytes is observed in major depression.
  • SERT plays a crucial role in regulating serotonin levels, impacting mood and behavior.

Purpose of the Study:

  • To investigate serotonin transporter mRNA levels in lymphocytes of major depression patients.
  • To explore the association between SERT gene polymorphism (5-HTTLPR) and mRNA levels in depression.

Main Methods:

  • RT-PCR was used to quantify serotonin transporter mRNA in lymphocytes from 29 major depression patients and 30 controls.
  • 5-HTTLPR polymorphism analysis was performed.
  • Immunofluorescence and cell counting (CD3+) were utilized to assess lymphocyte populations.

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Main Results:

  • Depressed patients showed significantly reduced serotonin transporter mRNA levels, particularly those expressing the long allele of the 5-HTTLPR gene.
  • The number of immunofluorescent lymphocytes and CD3+ lymphocytes was lower in patients with major depression.
  • No significant differences were found in serotonin or 5-HIAA levels between groups.

Conclusions:

  • The reduction in lymphocyte serotonin transporter in major depression may stem from decreased mRNA levels and fewer expressing cells.
  • These findings suggest a potential link between nervous-immune system interactions and the pathophysiology of depression.