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Exploratory activity and spatial learning in 12-month-old APP(695)SWE/co+PS1/DeltaE9 mice with amyloid plaques
R Lalonde1, H D Kim, J A Maxwell
1Université de Rouen, Faculté de Médecine et de Pharmacie, 22 bld Gambetta, INSERM U614, IFRMP 23, Bâtiment de Recherche, 76183 Rouen Cedex, France. robert.lalonde@univ-rouen.fr
Neuroscience Letters
|September 20, 2005
Summary
APP(695)SWE/co+PS1/DeltaE9 mice exhibit spatial learning deficits and disinhibited behavior, suggesting a selective cognitive impairment in this amyloid pathology mouse model.
Area of Science:
- Neuroscience
- Genetics
- Animal Models
Background:
- Alzheimer's disease is characterized by amyloid pathology.
- Mouse models are crucial for studying Alzheimer's disease mechanisms.
- APP(695)SWE/co+PS1/DeltaE9 mice develop amyloid plaques.
Purpose of the Study:
- To evaluate cognitive functions in APP(695)SWE/co+PS1/DeltaE9 mice.
- To assess exploratory activity and spatial learning in a mouse model of amyloid pathology.
- To identify behavioral phenotypes associated with amyloid deposition.
Main Methods:
- Behavioral testing including elevated plus-maze, open-field, T-maze, and Morris water maze.
- Assessment of exploratory activity and spatial learning.
- Comparison between 12-month-old bigenic mice and non-transgenic controls.
Main Results:
- APP(695)SWE/co+PS1/DeltaE9 mice showed increased time in open arms of elevated plus-maze, indicating disinhibition.
- Bigenic mice traveled farther in open-field central region but without increased time.
- Impaired acquisition and probe trial performance in Morris water maze (hidden platform), but not visible platform test.
- Successful alternation above chance in T-maze by bigenic mice.
Conclusions:
- APP(695)SWE/co+PS1/DeltaE9 mice display a selective spatial learning deficit.
- These mice exhibit disinhibitory tendencies.
- This mouse model serves as a valuable tool for studying amyloid pathology and associated cognitive impairments.