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Suicide among Danes with multiple sclerosis.

H Brønnum-Hansen1, E Stenager, E Nylev Stenager

  • 1National Institute of Public Health, Øster Farimagsgade 5, DK-1399 Copenhagen K, Denmark. hbh@niph.dk

Journal of Neurology, Neurosurgery, and Psychiatry
|September 20, 2005
PubMed
Summary

Individuals with multiple sclerosis (MS) face more than double the suicide risk compared to the general population. This elevated risk persists for over 20 years post-diagnosis and has not decreased since 1953.

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Area of Science:

  • Neurology
  • Epidemiology
  • Public Health

Background:

  • Multiple sclerosis (MS) is a chronic neurological disease with significant physical and psychological impacts.
  • Understanding the mental health burden, specifically suicide risk, in MS populations is crucial for patient care and support.

Purpose of the Study:

  • To compare suicide risk in Danish citizens diagnosed with multiple sclerosis against the general population.
  • To analyze trends and changes in suicide risk among MS patients over a 45-year period.

Main Methods:

  • Utilized data linkage between the Danish Multiple Sclerosis Registry and the Cause of Death Registry.
  • Included 10,174 individuals diagnosed with MS between 1953 and 1996, with follow-up until January 1999.
  • Calculated standardized mortality ratios (SMRs) based on time since diagnosis, age, and calendar period.

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Main Results:

  • The overall suicide risk for individuals with MS was more than double that of the general population (SMR = 2.12).
  • A significantly higher risk was observed in the first year post-diagnosis (SMR = 3.15).
  • The excess suicide risk remained elevated, even more than 20 years after diagnosis.

Conclusions:

  • Individuals with multiple sclerosis exhibit a substantially higher risk of suicide compared to the general population.
  • This increased suicide risk is a long-term concern, persisting for decades after diagnosis.
  • There has been no observed decline in this excess suicide risk since 1953, highlighting a persistent public health issue.