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Related Experiment Videos

Age-related attenuation in the elements in monkey sino-atrial node.

Hiroyasu Satoh1, Setsuko Tohno, Cho Azuma

  • 1Cooperation Research Program, Primate Research Institute, Kyoto University, Kyoto, Japan.

Biological Trace Element Research
|September 20, 2005
PubMed
Summary

Aging decreases essential trace elements in the sino-atrial (SA) node, impacting heart function. This study found significant reductions in calcium and phosphorus in aging monkey hearts, suggesting cellular changes affect cardiac performance.

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Area of Science:

  • Cardiovascular Physiology
  • Gerontology
  • Trace Element Analysis

Background:

  • Sino-atrial (SA) node function declines with age, associated with decreased sympathetic activity.
  • Understanding age-related changes in SA node composition is crucial for explaining cardiac function deterioration.

Purpose of the Study:

  • To investigate the changes in trace element concentrations within the SA node during aging.
  • To correlate these elemental changes with age-dependent functional decline in cardiac pacemakers.

Main Methods:

  • Analysis of trace elements (Ca, P, S, Mg, Na, Fe, Zn) in SA nodal tissue from Japanese and rhesus monkeys across a wide age range (27 days to 30 years).
  • Utilized Inductively Coupled Plasma-Atomic Emission Spectrometry (ICP-AES) for precise elemental quantification.

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  • Histological examination confirmed SA nodal tissue integrity.

    • Main Results:

    • Advancing age led to a decrease, not an increase, in SA node trace element content.
    • Significant negative correlations were found between age and calcium (r = -0.561, p < 0.01) and phosphorus (r = -0.482, p < 0.05) levels.
    • Inter-elemental relationships were observed, particularly between Ca, P, S, Zn, and Na.

    Conclusions:

    • Trace element levels in the monkey SA node are attenuated with age.
    • These age-related elemental reductions may contribute to suppressed cardiac function due to histological alterations in SA nodal cells.