On the perfluorocarbon emulsions of second generation

Area of Science:

• Medicinal Chemistry
• Materials Science
• Biotechnology

Background:

• Perfluorocarbon-emulsions (PFC-emulsions) are crucial for oxygen delivery applications.
• Development of advanced PFC-emulsions requires novel perfluorocarbon compounds with dual functionality.

Purpose of the Study:

• To synthesize novel perfluorocarbons (F-dimorpholines, F-dipiperidines, F-cyclohexylmorpholine) for PFC-emulsion formulation.
• To investigate the role of these compounds as oxygen carriers and interfacial active compounds (IFACs).
• To introduce a new theory explaining the stabilizing effect of IFACs and test biocompatibility of novel fluorosurfactants.

Main Methods:

• Synthesis of new perfluorocarbons and fluorosurfactants.
• Characterization of synthesized compounds for their interfacial activity.
• Evaluation of biocompatibility of novel fluorosurfactants.
• Interpretation of the stabilizing effects of IFACs in PFC-emulsions.

Main Results:

• Successfully synthesized novel perfluorocarbons (F-dimorpholines, F-dipiperidines, F-cyclohexylmorpholine) with dual oxygen-carrying and interfacial activity.
• Introduced a new theory to explain the stabilizing effect of IFACs in PFC-emulsions.
• Synthesized and tested new classes of fluorosurfactants for biocompatibility.

Conclusions:

• The synthesized perfluorocarbons serve as effective oxygen carriers and interfacial active compounds for advanced PFC-emulsion formulation.
• The novel theory provides a better understanding of PFC-emulsion stabilization.
• The tested fluorosurfactants show potential for use in biocompatible formulations.