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Updated: Aug 15, 2026

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
Published on: February 3, 2012
[Occurrence of autoimmune chronic hepatitis in siblings]
Darko Nozić1, Jovan Dimitrijević, Slavica Knezević-Usaj
1Vojnomedicinska akademija, Klinika za infektivne i tropske bolesti, Beograd, Srbija i Crna Gora.
Background:
Autoimmune hepatitis is a chronic inflamatory disease of the liver of unknown etiology, characterized by the loss of tolerance against hepatic tissue, leading to the destruction of hepatic parenchyma. It predominantly affects females, and rarely occurs in the same family.
Case Report:
In this paper we presented brother and sister with autoimmune hepatitis according to the criteria of the International Autoimmune Hepatitis Group.
Conclusion:
Because of a possible genetic predisposition to autoimmune hepatitis, the occurrence of the disease in a family member suggested the need to examine other family members.
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