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Does endogenous testosterone mediate the lower preconditioning threshold in males?

Nicholas T Nelson1, Adam J Mahomed, Jeffrey M Pitcher

  • 1Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.

The Journal of Surgical Research
|September 21, 2005
PubMed
Summary
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Testosterone does not explain why males have a lower preconditioning threshold. This study found that castration did not alter the protective effects of preconditioning in male rats.

Area of Science:

  • Physiology
  • Endocrinology
  • Cardiovascular Research

Background:

  • Preconditioning confers protection against subsequent injury.
  • Males exhibit lower preconditioning thresholds than females.
  • Testosterone is hypothesized to mediate this sex-based difference.

Purpose of the Study:

  • To investigate the role of endogenous testosterone in mediating the lower preconditioning threshold in males.
  • To determine if castration affects the preconditioning response in male rats.

Main Methods:

  • Adult male rats, both intact and castrated, were subjected to preconditioning with varying doses of lipopolysaccharide (ETX).
  • A subsequent injury dose of ETX was administered 24 hours later.
  • Myocardial function was assessed using the Langendorff perfusion model.

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Main Results:

  • Preconditioned intact and castrated males maintained cardiac function comparable to shams.
  • Non-preconditioned males (PC-) in both groups showed significantly reduced cardiac function.
  • Castration did not abolish the preconditioning effect in male rats.

Conclusions:

  • Endogenous testosterone does not appear to mediate the lower preconditioning threshold observed in males.
  • The preconditioning effect is preserved in castrated males, suggesting other factors are involved.