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Scrapie.

L A Detwiler1

  • 1United States Department of Agriculture, Animal and Plant Health Inspection Service, Trenton, New Jersey 08619.

Revue Scientifique Et Technique (International Office of Epizootics)
|June 1, 1992
PubMed
Summary

This review details scrapie, a sheep disease, covering its history, spread, causes, and control. It also discusses the disease agent and genetic factors influencing its incubation period.

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Area of Science:

  • Veterinary Medicine
  • Epidemiology
  • Animal Pathology

Background:

  • Scrapie is a fatal, transmissible spongiform encephalopathy affecting sheep and goats.
  • Understanding its epidemiology and pathogenesis is crucial for disease control.
  • Previous reviews have not comprehensively covered all aspects of scrapie.

Purpose of the Study:

  • To provide a detailed review of scrapie in sheep.
  • To discuss the disease agent, genetic influences, and transmission dynamics.
  • To outline national and international control efforts.

Main Methods:

  • Comprehensive literature review of historical and current research on scrapie.
  • Analysis of epidemiological data, clinical presentations, and pathological findings.
  • Synthesis of information on disease causation, diagnosis, and economic impact.

Main Results:

  • Scrapie's history, global distribution, and economic effects are detailed.
  • The nature of the scrapie agent, genetic control of incubation, and transmission are discussed.
  • National control strategies and their effectiveness are outlined.

Conclusions:

  • Scrapie remains a significant concern in sheep and goat populations worldwide.
  • Effective control requires a thorough understanding of the disease's multifaceted aspects.
  • Continued research and coordinated international efforts are essential for managing scrapie.

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