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Structural arrangement of DNA constrained by a cross-linker

Masayuki Endo¹, Tetsuro Majima

¹The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan. endo@sanken.osaka-u.ac.jp

Organic & Biomolecular Chemistry

|September 21, 2005

Abstract:

Self-complementary cross-linked oligonucleotides with a disulfide linkage were designed and synthesized. Double helix and hairpin structures were controlled using the different diastereochemistry of phosphoramidate where the cross-linker was introduced. The structures of the strained cross-linked DNAs were estimated by gel mobility, circular dichroism spectra, and melting profiles.

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