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Imbalance between soluble tumour necrosis factor receptors type 1 and 2 in chronic periodontitis

Ikuyo Ikezawa1, Hideaki Tai, Yasuko Shimada

  • 1Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Journal of Clinical Periodontology
|September 22, 2005
PubMed
Abstract

Insights

Tumour necrosis factor (TNF) receptors in gingival crevicular fluid (GCF) increase with chronic periodontitis (CP) severity. An imbalance between soluble TNF receptor type 1 and 2 in GCF may indicate CP progression.

Area of Science:

  • Periodontology
  • Immunology
  • Biochemistry

Background:

  • Soluble tumour necrosis factor (TNF) receptors type 1 and 2 modulate TNF-alpha-mediated inflammation in chronic periodontitis (CP).
  • Understanding these receptor levels in CP is crucial for inflammatory response insights.

Purpose of the Study:

  • To investigate and compare levels of TNF-alpha, soluble TNF receptor type 1, and soluble TNF receptor type 2.
  • To analyze these levels in gingival crevicular fluid (GCF) and serum of healthy individuals and CP patients.

Main Methods:

  • Collected 38 serum and 73 GCF samples from 16 healthy subjects and 22 CP patients.
  • Quantified TNF-alpha, soluble TNF receptor type 1, and soluble TNF receptor type 2 using enzyme-linked immunosorbent assay.
  • Analyzed GCF from sites with varying probing pocket depths (PPD).

Main Results:

  • TNF-alpha, soluble TNF receptor type 1, and soluble TNF receptor type 2 levels in GCF significantly increased with probing pocket depth (PPD).
  • Soluble TNF receptor type 2 levels were lower than type 1 as pocket depths increased.
  • The ratio of soluble TNF receptor type 2 to type 1 in GCF decreased significantly with increasing periodontitis severity.

Conclusions:

  • The observed imbalance between soluble TNF receptor type 1 and 2 levels in GCF correlates with chronic periodontitis severity.
  • This imbalance may serve as a potential biomarker for assessing CP progression.

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