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Updated: Aug 15, 2026

A Protocol for Safe Lithiation Reactions Using Organolithium Reagents
Published on: November 12, 2016
Lithium: a review of its metabolic adverse effects
Callum Livingstone1, Hagan Rampes
1Clinical Biochemistry Department, Royal Surrey County Hospital, Guildford, Surrey, UK. clivingstone@royalsurrey.nhs.uk
Abstract:
Treatment with lithium has long been recognized to be associated with metabolic adverse effects notably hypothyroidism, hyperparathyroidism, weight gain and nephrogenic diabetes insipidus. It is important that clinicians prescribing lithium are aware of these adverse effects and have a strategy for their detection and management. We review aspects of these actions of lithium including their prevalence, risk factors, biochemical changes involved and management, and discuss some advances that have been made in their understanding in recent years.
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