Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Functioning ovarian carcinoids induce severe constipation.

T Motoyama1, Y Katayama, H Watanabe

  • 1Department of Pathology, Niigata University School of Medicine, Japan.

Cancer
|July 15, 1992
PubMed
Summary

Ovarian carcinoid tumors in five patients caused severe constipation. This symptom improved after surgery, likely due to the tumor producing peptide YY (PYY), which slows intestinal movement.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Visualize the quality of frozen fish using fluorescence imaging aided with excitation-emission matrix.

Optics express·2018
Same author

Joint lavage followed by viscosupplementation and triamcinolone in patients with severe haemophilic arthropathy: objective functional results.

Haemophilia : the official journal of the World Federation of Hemophilia·2016
Same author

Fluorescent estimation on cytotoxicity of methylmercury in dissociated rat cerebellar neurons: its comparison with ionomycin.

Environmental toxicology and pharmacology·2011
Same author

Effects of triphenyltin on growth and viability of K562 leukemia cells.

Environmental toxicology and pharmacology·2011
Same author

Measurement of /V(ub)/ using inclusive B-->X(u)lnu decays with a novel X(u)-reconstruction method.

Physical review letters·2004
Same author

Observation of the radiative decay D0-->phigamma.

Physical review letters·2004

Area of Science:

  • Gastroenterology
  • Endocrinology
  • Oncology

Background:

  • Ovarian carcinoid tumors can present with severe, long-term constipation.
  • The cause of constipation in these cases is hypothesized to be a biologically active substance, not solely mechanical compression.

Purpose of the Study:

  • To investigate the potential role of peptide hormones in causing constipation associated with ovarian carcinoid tumors.
  • To identify specific biologically active substances produced by the tumors.

Main Methods:

  • Immunohistochemical analysis of tumor tissue from five patients with ovarian carcinoid and preoperative constipation.
  • Assessment of reactivity to 17 amine and peptide hormones.

Main Results:

Related Experiment Videos

  • A high prevalence of peptide YY (PYY)-positive cells was observed in all studied carcinoid tumors.
  • PYY-positive cells constituted over 50% of tumor cells in each patient.
  • Postoperative reduction in constipation symptoms was noted.

    • Conclusions:

    • Peptide YY (PYY) is strongly implicated as the causative agent of severe constipation in patients with ovarian carcinoid tumors.
    • PYY's pharmacologic action of inhibiting intestinal motility likely explains the observed symptom.