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Related Experiment Videos

Tablets prepared by single-step granulation/tabletting: interparticulate binding mechanism and stability.

A Vermeire1, E I Keleb, F Kiekens

  • 1Laboratory of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium.

Pharmaceutical Development and Technology
|September 24, 2005
PubMed
Summary

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Single-step granulation/tabletting (SSGT) produces strong, porous tablets via solid bridges. However, high humidity can weaken these tablets by affecting the binder and pore surfaces.

Area of Science:

  • Pharmaceutical technology
  • Materials science
  • Physical chemistry

Background:

  • Conventional tablet manufacturing involves multiple steps, potentially impacting tablet properties.
  • Single-step granulation/tabletting (SSGT) is a novel technique for tablet production.
  • Understanding the binding mechanism in SSGT is crucial for optimizing tablet quality.

Purpose of the Study:

  • To evaluate the binding mechanism of tablets produced by single-step granulation/tabletting (SSGT).
  • To compare the mechanical properties and stability of SSGT tablets with conventionally manufactured tablets.
  • To investigate the effect of humidity on the tensile strength of SSGT tablets.

Main Methods:

  • Calculation of the interaction factor.
  • Electrical conductance tests.

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  • Moisture sorption analysis.
  • Tensile strength measurements under varying relative humidity.

    • Main Results:

    • SSGT tablets exhibited a porous, sponge-like structure, leading to hardness and short disintegration times.
    • Solid bridges were confirmed, contributing to higher tensile strength compared to conventional tablets.
    • High relative humidity reduced tensile strength due to binder transitions or moisture condensation.
    • SSGT tablets did not harden during storage under alternating humidity, unlike conventional tablets.

    Conclusions:

    • SSGT is an effective technique for producing tablets with desirable mechanical properties.
    • The porous structure and solid bridges are key to the enhanced strength of SSGT tablets.
    • Tablet stability under varying humidity is a critical factor, with SSGT showing an advantage over conventional methods in this regard.