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Total synthesis of (-)-SNF4435 C and (+)-SNF4435 D
Christopher M Beaudry1, Dirk Trauner
1Department of Chemistry, University of California, Berkeley, California 94720, USA.
Abstract:
[reaction: see text] A convergent, biomimetic total synthesis of the immunosuppressant polyketides SNF4435 C and D is described. The synthetic pathway features a stereo- and regioselective [3,3]-sigmatropic rearrangement as well as a high-yielding Stille coupling/8pi-6pi electrocyclization cascade.
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