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Related Experiment Videos

Association between atopy and recurrent vaginal candidiasis.

N A Neves1, L P Carvalho, M A M De Oliveira

  • 1Serviço de Imunologia, Hospital Universitario Prof Edgard Santos, Universidade Federal da Bahia, Salvador, Bahia, Brazil.

Clinical and Experimental Immunology
|September 24, 2005
PubMed
Summary

Women with recurrent vaginal candidiasis (RVC) have a higher prevalence of atopy, an allergic condition. However, the study found no evidence of a type-2 immune response to Candida albicans in RVC patients.

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Area of Science:

  • Immunology
  • Gynecology
  • Allergology

Background:

  • Recurrent vaginal candidiasis (RVC) affects a significant number of women.
  • The role of atopy and specific immune responses in RVC pathogenesis remains unclear.

Purpose of the Study:

  • To investigate the association between atopy and RVC.
  • To evaluate the type-2 immune response in women with RVC compared to those with sporadic vaginal candidiasis (SVC).

Main Methods:

  • Immediate hypersensitivity skin tests to aeroallergens were performed.
  • Measurements included total IgE, Candida albicans specific IgE, and IL-5 levels.
  • 44 women with RVC and 26 with SVC were analyzed using Mann-Whitney and chi(2) tests.

Main Results:

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  • A history of atopy (68%) and positive skin tests (42%) were significantly higher in the RVC group (P < 0.05).
  • No significant differences were observed in total IgE, C. albicans specific IgE, or IL-5 levels between RVC and SVC groups.
  • A strong association between atopy and RVC was identified.

Conclusions:

  • Atopy is strongly associated with recurrent vaginal candidiasis.
  • The study did not find evidence of a type-2 immune response to Candida albicans in women with RVC.