Related Experiment Video
Updated: Aug 15, 2026

04:44
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Scleroderma and pseudo-scleroderma: uncommon presentations
1Department of Dermatology, Venerology and Allergology, University of Leipzig, D-04103 Leipzig, Germany. ufh@medizin.uni-leipzig.de
Clinics in Dermatology
|September 24, 2005
Summary
Scleroderma presents with distinct symptoms, but other diseases can mimic it. This review explores unusual scleroderma presentations and conditions that resemble scleroderma.
Area of Science:
- Rheumatology
- Dermatology
- Internal Medicine
Background:
- Scleroderma exhibits characteristic clinical features.
- Differential diagnosis is crucial as other conditions can mimic scleroderma.
- Atypical presentations of scleroderma and pseudo-scleroderma diseases are common.
Purpose of the Study:
- To discuss uncommon presentations of true scleroderma.
- To review variants of scleroderma.
- To describe pseudo-scleroderma diseases.
Main Methods:
- Literature review of scleroderma and pseudo-scleroderma.
- Analysis of clinical presentations.
- Case study review.
Main Results:
- Scleroderma can manifest in unusual ways.
- Several unrelated diseases can mimic scleroderma's key features.
- Distinguishing true scleroderma from mimics requires careful evaluation.
Conclusions:
- Understanding atypical scleroderma presentations is vital for accurate diagnosis.
- Recognition of pseudo-scleroderma conditions improves patient management.
- This review aids clinicians in diagnosing challenging cases.
Related Concept Videos
Skin Cancer
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Reticular Dermis
The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Clinical Applications of Epidermal Stem Cells
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...