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Considerable differences between methods for plasma D-dimer in the diagnosis of venous thrombosis: increased positive
Y Björk1, C Hall, H von Schenck
1Department of Internal Medicine, Varberg Hospital, Varberg, Sweden.
Abstract:
Four analytical methods for plasma D-dimer have been compared in a group of 82 consecutive patients with suspected venous thrombosis, 22 of whom subsequently received a positive clinical diagnosis. Differences in diagnostic power between methods were observed. In three of the four methods tested, the use of elevated discriminatory limits (rather than conventional 95-percentile upper reference limits) resulted in stronger positive predictive values for thromboembolism. We suggest that this approach may result in better diagnostic performance of the D-dimer method.
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