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Related Experiment Videos

Discovery genetics: serendipity in basic research.

Muriel T Davisson1

  • 1Genetic Resources, The Jackson Laboratory, Bar Harbor, ME, USA.

ILAR Journal
|September 24, 2005
PubMed
Summary
This summary is machine-generated.

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Serendipity plays a crucial role in discovering new mouse models through spontaneous mutations. Alert researchers can exploit these chance observations for valuable research opportunities.

Area of Science:

  • Genetics and Genomics
  • Animal Models
  • Scientific Discovery

Background:

  • Spontaneous mutations in research mice are a source of novel genetic variations.
  • Forward genetics, which identifies genes based on observed phenotypes, often relies on unexpected findings.
  • The Jackson Laboratory has a program focused on leveraging serendipitous discoveries in mouse colonies.

Purpose of the Study:

  • To describe the role of serendipity in discovering and developing mouse models with spontaneous mutations.
  • To explain how scientists can utilize serendipitous discoveries as a research strategy.
  • To highlight the importance of observant researchers in capitalizing on unexpected findings.

Main Methods:

  • Observing and identifying unexpected phenotypes in large mouse breeding colonies.

Related Experiment Videos

  • Utilizing forward genetics approaches to analyze spontaneous mutations.
  • Implementing a program to systematically capitalize on serendipitous discoveries.

    • Main Results:

    • Spontaneous mutations occur naturally in all research mouse colonies.
    • Unexpected phenotypes resulting from these mutations can be identified.
    • These chance observations can be rationally exploited to create new research models.

    Conclusions:

    • Serendipity is a vital, albeit unplanned, component in the discovery of new mouse models for research.
    • Scientists and technicians can adopt a proactive strategy to leverage unexpected observations for scientific advancement.
    • The development of mouse models for human disease is significantly advanced through the exploitation of spontaneous mutations.