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[Distigmine bromide induced Parkinsonism. A case report]
Shoichiro Sato1, Koichiro Nakamura, Toshiki Nakahara
1Department of Neurology, Fukushima Medical University.
Rinsho Shinkeigaku = Clinical Neurology
|September 27, 2005
Summary
Distigmine bromide, used for constipation, can induce Parkinsonism. A 74-year-old man experienced Parkinsonian symptoms after starting the medication, which resolved upon discontinuation.
Area of Science:
- Neurology
- Pharmacology
Background:
- Distigmine bromide is a medication sometimes prescribed for constipation.
- Parkinsonism is a neurological disorder characterized by movement difficulties.
Observation:
- A 74-year-old male patient developed severe mobility issues, including bradykinesia, rigidity, and tremor, shortly after initiating oral distigmine bromide (10 mg/day).
- Neurological examination confirmed Parkinsonian symptoms without lateralization.
- Brain MRI revealed mild front-temporal atrophy and white matter hyperintensities.
Findings:
- The patient's Parkinsonian symptoms fully resolved within one week of discontinuing distigmine bromide.
- This case represents the first reported instance of distigmine bromide-induced Parkinsonism.
Implications:
- This report highlights a potential adverse drug reaction to distigmine bromide, suggesting a need for increased clinical awareness.
- Healthcare providers should consider drug-induced Parkinsonism in patients presenting with relevant symptoms, especially after starting distigmine bromide.
- Further research may be warranted to understand the mechanism and prevalence of this adverse effect.