Related Experiment Video
Updated: Aug 14, 2026

Motor and Hippocampal Dependent Spatial Learning and Reference Memory Assessment in a Transgenic Rat Model of Alzheimer's Disease with Stroke
Published on: March 22, 2016
From brain ischemia-reperfusion injury to possible sporadic Alzheimer's disease
1Department of Neurodegenerative Disorders, Medical Research Center, Polish Academy of Sciences, 02-106 Warsaw, Pawinskiego 5 Str., Poland. pluta@medres.cmdik.pan.pl
Abstract:
Understanding of the molecular basis of dementias such as Alzheimer's disease has not improved greatly in recent years. In this situation the study of neurobiology of Alzheimer's disease, now more than ever, needs an infusion of new concept. Recent evidence suggests that the neuropathological picture of Alzheimer's disease comprises more than amyloid accumulation, neurofibrillary tangles and finally brain atrophy. At least one third of Alzheimer type of dementia cases exhibit different cerebrovascular diseases. In addition, micro- and macro-infarctions and ischemic white matter changes are also evident in brains of Alzheimer's disease patients. The presence of vascular abnormalities seems usually ignored and regarded by researchers as insignificant or considered incidental in Alzheimer's disease etiology. The "ischemia-reperfusion hypothesis" was primarily aimed at stimulating research and redirecting the focus of studies towards ischemic cellular mechanisms of Alzheimer's disease. Considerable progress has been made in recent years in understanding the role of ischemia in the aging process and in contributing to the development of Alzheimer's disease. To accommodate the recent ischemic progress of study in Alzheimer's disease there is a need to synthesize all the divergent pieces of data into a coherent story. In this review, current knowledge on the relation between cerebrovascular disease factors and Alzheimer's type dementia will be reviewed. We will summarize the results with a special focus on Alzheimer lesions in experimental brain ischemia.
Related Concept Videos
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Ischemic Stroke ll: Pathophysiology
Cerebral Edema ll: Pathophysiology
Alzheimer Disease l: Introduction
Alzheimer Disease ll: Pathophysiology
Dementia l: Introduction

