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Updated: Aug 15, 2026

Modeling Neonatal Intraventricular Hemorrhage Through Intraventricular Injection of Hemoglobin
Published on: August 25, 2022
Thrombophilia and fetal germinal matrix-intraventricular hemorrhage: does it matter?
L A Ramenghi1, M Fumagalli, A Righini
1Neonatal Intensive Care Unit, L. Mangiagalli Hospital, IRCCS, University of Milan, Milan, Italy. lucrameng@hotmail.com
Abstract:
Germinal matrix-intraventricular hemorrhage (GMH-IVH) in the fetus is very rare and the role of thrombophilia in its pathogenesis is unclear. We report on the prenatal diagnosis by magnetic resonance imaging of GMH-IVH in a 24-week fetus. The newborn presented posthemorrhagic ventriculomegaly and was found to be heterozygous for two thrombophilic patterns, factor V Leiden and methylenetetrahydrofolate reductase mutation. The combination of this hypercoagulable state and prenatal GMH-IVH is discussed together with the opportunity of testing these infants for thrombophilia.
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