Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Sapphire: precious stone or ersatz?].

R Limet1

  • 1Département de Chirurgie, CHU Sart Tilman, Liège.

Revue Medicale De Liege
|September 28, 2005
PubMed
Summary

Carotid artery stenting was found to be non-inferior to carotid endarteriectomy in high-risk patients. However, the SAPPHIRE trial data faced significant controversy regarding potential biases and surgical outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In Memoriam J.C. Lavigne, past president RBSS 1982.

Acta chirurgica Belgica·2016
Same author

Histologic characterization of carotid plaques.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2015
Same author

[From Hippocrates to Harvey: twenty centuries of research on circulation].

Revue medicale de Liege·2010
Same author

[Image of the month. A case of aortic regurgitation association with dexfenfluramine].

Revue medicale de Liege·2009
Same author

[Cardiac metastasis from malignant melanoma].

Revue medicale de Liege·2009
Same author

[Modern look at a pathology of the millenium: abdominal aortic aneurysms].

Bulletin et memoires de l'Academie royale de medecine de Belgique·2009

Area of Science:

  • Vascular Surgery
  • Interventional Cardiology
  • Clinical Trials

Context:

  • The SAPPHIRE trial evaluated carotid artery stenting (CAS) versus carotid endarteriectomy (CEA) in patients with carotid artery stenosis and high surgical risk.
  • This study aimed to determine the safety and efficacy of CAS with embolic protection compared to CEA.

Purpose:

  • To analyze and summarize potential biases and controversies surrounding the SAPPHIRE trial data.
  • To critically assess the surgical outcomes reported in the SAPPHIRE trial in comparison to existing literature.

Summary:

  • The SAPPHIRE trial concluded that carotid artery stenting was not inferior to carotid endarteriectomy in high-risk patients.
  • Despite its recognition, the trial's findings generated significant debate regarding data integrity and surgical performance.
  • The analysis highlights discrepancies between SAPPHIRE's surgical results and established benchmarks.

Impact:

  • The study's findings and subsequent controversies influenced clinical practice guidelines and future research directions in stroke prevention.
  • It underscored the importance of rigorous trial design and transparent reporting in interventional cardiovascular medicine.
  • The critical review of SAPPHIRE data contributes to a more nuanced understanding of treatment options for carotid artery stenosis.

Related Experiment Videos