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Influence of FcgammaRIIA and MBL polymorphisms on severe acute respiratory syndrome

F F Yuan1, J Tanner, P K S Chan

  • 1Australian Red Cross Blood Service-Endeavour, Sydney, NSW, Australia. fyuan@arcbs.redcross.org.au

Tissue Antigens
|September 28, 2005
PubMed

Insights

Genetic variations in the Fc gamma-receptor IIA (FcgammaRIIA) gene are linked to severe SARS-CoV outcomes. Mannose-binding lectin (MBL) gene polymorphisms did not show significant associations with SARS infection severity.

Area of Science:

  • Immunogenetics
  • Infectious Disease Epidemiology

Background:

  • Genetic polymorphisms in Fc gamma-receptor IIA (FcgammaRIIA) and mannose-binding lectin (MBL) are implicated in infectious disease susceptibility and severity.
  • The role of these genetic factors in severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infection remains unclear.

Purpose of the Study:

  • To investigate the association between FcgammaRIIA and MBL gene polymorphisms and susceptibility, course, and severity of SARS-CoV infection in a Hong Kong population.

Main Methods:

  • Genotyping of FcgammaRIIA and MBL genes was performed on DNA samples from approximately 180 SARS-CoV patients (categorized by disease severity) and 200 healthy controls.
  • Statistical analyses, including odds ratios and confidence intervals, were used to compare genotype frequencies between patient subgroups and controls.

Main Results:

  • A significant association was observed between the FcgammaRIIA-R/R131 genotype and a severe SARS-CoV course, with higher frequency in intensive care unit (ICU) patients compared to controls (P=0.03).
  • A trend analysis revealed lower incidence of the FcgammaRIIA-H/H131 genotype in severe SARS patients without co-morbidity.
  • No significant differences in MBL genotypes or allele frequencies were found between SARS patients and controls.

Conclusions:

  • FcgammaRIIA gene polymorphism, specifically the FcgammaRIIA-R/R131 genotype, may influence the outcome and severity of SARS-CoV infection.
  • Age and co-morbidity, alongside FcgammaRIIA genotype, are potential determinants of SARS-CoV infection severity.

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