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Exon 2 sequence analysis of a novel HLA-DRB1 allele, DRB1*1450

H J Tijssen1, S C van der Zeeuw-Hingrez, I Joosten

  • 1Department of Blood Transfusion and Transplantation Immunology, Radbould University Nymegen Medical Centre, Nymegen, The Netherlands.

Tissue Antigens
|September 28, 2005
PubMed
Abstract

No abstract available in PubMed .

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Exon Recombination02:32

Exon Recombination

The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
Exon shuffling follows “splice frame rules.” Each exon has three reading...