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Evaluation of 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer-coated dressing on surgical wounds
Osamu Katakura1, Nobuyuki Morimoto, Yasuhiko Iwasaki
1Oral Implantology and Regenerative Dental Medicine, Graduate school, Tokyo Medical and Dental University , Japan. ok.mfc@tmd.ac.jp
Abstract:
The ideal dressing material is bio-inert and keeps the wound site moist. It is equally important that no regenerative tissue is peeled off on the removal of the dressing. 2-Methacryloyloxyethyl phosphorylcholine (MPC) has a phospholipid polar group that mimics a biomembrane. We prepared poly [MPC-co-n-dodecyl methacrylate (DMA)] (PMD), using conventional radical polymerization with 2,2'-azobisisobutyronitrile as an initiator, and coated it on polyurethane (PU; Tecoflex 60 Thermedics Inc.) membrane. Full-thickness surgical wounds were made on the dorsal skin of rats and wound healing was compared under the following three conditions: air-exposed control (no dressing), PU dressing, and PMD dressing. At 3, 4 and 7 days after the operation, the wound sizes of the PMD dressings were smaller than the non-dressed wound, and at 6 and 7 days after the operation, the wound sizes of PU dressing were smaller than that of the air-exposed group. But there were no significant difference between the PMD dressing group and PU dressing group. Histologically, scab formation was not observed on the PU or PMD-dressed wounds. However, in the air-exposed control, a scab was formed and re-epithelialization of the wound site was prevented. Additionally, no damage was observed in the histological section of PMD dressed wound after the wound was cured. These results indicate that PMD dressing (PMD-coated PU membrane) has the potential to provide an inert environment for wound healing as well as PU.
Insights
A new poly [MPC-co-n-dodecyl methacrylate (DMA)] (PMD) dressing coated on polyurethane (PU) shows potential for wound healing. This biomembrane-mimicking material, similar to PU, reduces wound size and prevents scab formation without damaging tissue.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Polymer Chemistry
Background:
- Ideal wound dressings are bio-inert, maintain moisture, and prevent tissue damage upon removal.
- 2-Methacryloyloxyethyl phosphorylcholine (MPC) possesses a phospholipid polar group that mimics natural biomembranes.
- Polymeric materials offer tunable properties for advanced wound care applications.
Purpose of the Study:
- To develop and evaluate a novel wound dressing material based on a copolymer of MPC and n-dodecyl methacrylate (DMA).
- To compare the efficacy of the developed poly [MPC-co-n-dodecyl methacrylate (DMA)] (PMD)-coated polyurethane (PU) dressing against PU alone and an air-exposed control in promoting wound healing.
- To assess the biocompatibility and tissue interaction of the PMD dressing during the healing process.
Main Methods:
- Synthesis of poly [MPC-co-n-dodecyl methacrylate (DMA)] (PMD) via radical polymerization.
- Coating of the synthesized PMD onto a polyurethane (PU) membrane.
- Creation of full-thickness surgical wounds on rat dorsal skin for comparative healing studies.
- Histological analysis to evaluate scab formation, re-epithelialization, and tissue damage.
Main Results:
- PMD-dressed wounds showed reduced size compared to air-exposed controls at 3, 4, and 7 days post-operation.
- PU-dressed wounds also exhibited smaller sizes than controls at 6 and 7 days, with no significant difference between PMD and PU groups.
- Scab formation was inhibited in both PU and PMD dressed wounds, unlike the air-exposed control where it hindered re-epithelialization.
- Histological examination revealed no damage to the PMD-dressed wound tissue after healing.
Conclusions:
- The PMD-coated PU membrane demonstrates potential as an inert wound healing environment, comparable to PU.
- The dressing effectively promotes wound size reduction and prevents detrimental scab formation.
- The material exhibits good biocompatibility, showing no adverse effects on healing tissue.
