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Updated: Aug 15, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
Severe hypothyroidism due to atrophic thyroiditis from second year of life influenced developmental outcome
J V Joergensen1, B Oerbeck, P Jebsen
1Department of Paediatric Research, Rikshospitalet University Hospital, Oslo, Norway.
Unlabelled:
From the second year of life a girl showed an insidious development of clinical hypothyroidism due to a non-goitrous lymphocytic thyroiditis without traceable circulating levels of thyroid antibodies measured by routine immunoassays. The diagnostic delay of this rare variant of atrophic thyroiditis caused persistent neuropsychological deficits.
Conclusion:
Her difficulties with speed of processing and working memory in particular could suggest a frontal deficit, possibly in the dorsolateral prefrontal circuit. This contrasts with findings in congenital hypothyroidism, suggesting a relatively preserved frontal function, and could illustrate different neuropsychological deficits of hypothyroidism at different ages in early childhood.
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