Development of tight junction molecules in blood vessels of germinal matrix, cerebral cortex, and white matter

Praveen Ballabh1, Furong Hu, Mithun Kumarasiri

  • 1Department of Pediatrics, Westchester Medicak Center--New York Medical College, Valhalla, 10595, USA. Pballabh@msn.com

Pediatric Research
|September 29, 2005
PubMed

Insights

Endothelial tight junction molecules like claudin-5 and occludin are present early in premature infant brains. Their expression does not decrease in the germinal matrix, suggesting they are not the cause of germinal matrix hemorrhage.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Vascular Biology

Background:

  • Tight junction (TJ) molecules are crucial for endothelial cell adhesion and blood vessel integrity.
  • Decreased TJ molecule expression is hypothesized to contribute to germinal matrix (GM) fragility and hemorrhage in premature infants.

Purpose of the Study:

  • To compare the expression of endothelial TJ molecules (claudin-5, occludin, JAMs) in the germinal matrix, cortex, and white matter of fetuses and premature infants.
  • To investigate the maturational changes of these TJ molecules with advancing gestational age.

Main Methods:

  • Postmortem brain samples from 16-40 weeks gestational age were analyzed.
  • Immunohistochemical staining and Western blot were used to quantify claudin-1, claudin-5, occludin, and JAM expression.

Main Results:

  • Claudin-5, occludin, and JAM-1 were expressed from 16 weeks gestational age in the GM, cortex, and white matter.
  • Expression levels of claudin-5, occludin, and JAM-1 did not significantly change with gestational age.
  • No significant differences in expression were found between GM vasculature and other brain regions.

Conclusions:

  • The primary endothelial TJ molecules (claudin-5, occludin, JAM-1) are expressed early and consistently in the developing brain vasculature.
  • These TJ molecules are unlikely to be the primary cause of germinal matrix fragility and hemorrhage in premature infants.

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