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Claudin-3 in pediatric disorders of gut-brain interaction: promise and questions
Mahmoud G El Baassiri1, Chhinder P Sodhi2
1Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Impact Statement:
This commentary discusses serum claudin-3 (CLDN3) as a potential non-invasive marker of intestinal barrier dysfunction in adolescents with functional gastrointestinal disorders. Its association with systemic inflammatory markers raises questions about the relationship between barrier dysfunction and inflammation, while highlighting the need for prospective validation before clinical use.
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