Segmental cholestasis drives global hepatic fibrosis: lessons from the sBDL model in weaned rats

This commentary provides a detailed analysis of Gonçalves et al.'s research paper, "Key genes and histopathological alterations in hepatic fibrogenesis after segmental cholestasis in weaned rats.¹" It emphasizes how segmental cholestasis caused by selective bile duct ligation in young rats leads to extensive hepatic fibrogenesis, affecting both obstructed and non-obstructed liver lobes-similar to pediatric cholangiopathies like biliary atresia and post-transplant strictures in children. It not only illustrates regional hepatic disease patterns but also offers a valid preclinical platform for testing antifibrotic treatments.