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Topical corticosteroids and Staphylococcus aureus in atopic dermatitis
E J Nilsson1, C G Henning, J Magnusson
1Department of Dermatology, Sundsvall Hospital, Sweden.
Journal of the American Academy of Dermatology
|July 1, 1992
Summary
Topical corticosteroids effectively reduce Staphylococcus aureus (S. aureus) colonization in atopic dermatitis. Higher potency corticosteroids led to greater S. aureus reduction, with elimination achieved using very potent options.
Area of Science:
- Dermatology
- Microbiology
- Pharmacology
Background:
- Atopic dermatitis frequently exhibits high-density colonization by Staphylococcus aureus.
- Staphylococcus aureus colonization is linked to atopic dermatitis severity.
Purpose of the Study:
- To investigate the impact of topical corticosteroids on Staphylococcus aureus colonization in atopic dermatitis patients.
- To assess the influence of corticosteroid potency on S. aureus reduction.
Main Methods:
- Sixty-six atopic dermatitis patients received moderately or very potent topical corticosteroids.
- Quantification of S. aureus and eczema severity assessments were conducted at baseline, 1 week, and 2 weeks.
Main Results:
- Pre-treatment S. aureus colonization was observed in 53 patients, correlating with eczema severity.
- Topical corticosteroids significantly reduced S. aureus density, with greater reduction seen with higher potency agents.
- The most significant reduction occurred within the first week of treatment; S. aureus was eliminated with very potent corticosteroids after two weeks.
Conclusions:
- Topical corticosteroids of adequate potency are effective in reducing Staphylococcus aureus density in atopic dermatitis.
- Corticosteroid potency directly influences the degree of S. aureus reduction.