Related Experiment Video
Updated: Aug 10, 2026

Using Retinal Imaging to Study Dementia
Published on: November 7, 2017
Pathophysiology of cerebral small vessels in vascular cognitive impairment
Leonardo Pantoni1, Michela Simoni
1Department of Neurological and Psychiatric Sciences, University of Florence, Italy. pantoni@neuro.unifi.it
Abstract:
Cerebral small-vessel alterations play a central role in determining lesions of subcortical structures and eventually may lead to cognitive impairment. Small-vessel diseases are classified according to the pathological viewpoint. The most important ones are the changes in small arteries and arterioles caused by prolonged hypertension. These small-vessel changes may result in ischemic damage to the brain parenchyma and blood-barrier alterations. Both mechanisms are thought to contribute to the occurrence of white-matter changes and lacunar infarcts. Modern magnetic resonance techniques such as diffusion, perfusion, and spectroscopy may allow the in vivo study of the pathophysiology of small-vessel diseases and the consequences on the brain parenchyma.
More Related Videos
07:30Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
Published on: April 23, 2021
05:12A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis
Published on: November 22, 2024
Related Concept Videos
Ischemic Stroke l: Introduction
Ischemic Stroke ll: Pathophysiology
Hemorrhagic Stroke ll: Pathophysiology
Transient Ischemic Attack l: Introduction
Cerebral Edema ll: Pathophysiology
Dementia l: Introduction