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Iopamidol in cardioangiography: a retrospective, multicentre study. Part II. Paediatric patients
L Ballerini1, F Barbaresi, G Binaghi
1Dipartimento di Cardiologia Pediatrica, Ospedale Bambin Gesù Roma, Italy.
Insights
This study analyzed 8,166 pediatric cardioangiography procedures using iopamidol. While overall complication rates were higher in children than adults, contrast medium complications and mortality were comparable, confirming iopamidol
Area of Science:
- Cardiology
- Pediatric Imaging
- Radiology
Background:
- Pediatric cardioangiography is essential for diagnosing congenital heart disease.
- Nonionic contrast media are preferred for their safety profile.
- Iopamidol is a commonly used nonionic contrast agent.
Purpose of the Study:
- To evaluate the complication rate of iopamidol in pediatric cardioangiography.
- To compare complication rates between pediatric and adult patients.
- To assess the safety and tolerability of iopamidol in young patients.
Main Methods:
- Retrospective analysis of 8,166 pediatric cardioangiography procedures.
- Data collected from 12 different centers.
- Complication rates categorized by procedure and contrast medium.
Main Results:
- Overall complication rate was 3.78% (procedure-related: 3.44%, contrast-related: 0.34%).
- Mortality rate varied by age, higher in infants (<2 months).
- Pediatric complication rates exceeded adult rates, but contrast-related issues and mortality were similar.
Conclusions:
- Iopamidol demonstrates good tolerability in pediatric cardiac catheterization.
- Higher complication rates in children are likely due to underlying health conditions.
- Iopamidol is a safe contrast medium for pediatric cardioangiography.
Abstract:
To evaluate the complication rate in paediatric cardioangiography with the nonionic contrast medium iopamidol data on 8,166 procedures were retrospectively collected in 12 centres. The overall complication rate was 3.78% (309/8,166). 3.44% were related to the procedure, and 0.34% to the contrast medium. The mortality rate varied with age. It was higher in patients less than 2 months (0.38%) than in patients greater than 2 months-2 years (0.06%) and in patients older than 2 years (0.03%). The total complication rate was higher than the one observed in a similar retrospective analysis performed in adult patients (1.89%). This difference is probably due to higher risk conditions of the younger patients. However the contrast medium related complication rate (0.34% vs 0.4%) and the mortality rate (0.11% vs 0.1%) were comparable, confirming the good tolerability of iopamidol in cardiac catheterisation also in paediatric patients.