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A general and versatile molecular design for host molecules working in water: a duplex-based potassium sensor
Kazuhisa Fujimoto1, Yu Muto, Masahiko Inouye
1Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan. fujimoto@ms.toyama-mpu.ac.jp
Abstract:
A general and versatile molecular design for host molecules was proposed based on the structural motif of antibodies. A water-soluble potassium sensor was developed by this molecular design, which consists of three functional regions, benzo-15-crown-5 ether, DNA, and pyrene as guest-binding, dimerising, and signaling sites, respectively. The molecular sensor emitted the monomer fluorescence of the pyrene fluorophore predominantly when existing as a random structure, while it formed a duplex upon recognition of K+ to bring about monomer-excimer emission switching.
