[Effects of the platelet activating factor on the proliferation and IgE secretion by U-266BL human myeloma cells]
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Abstract:
Platelet activating factor (PAF) influences the proliferation and IgE secretion by U-266BL human myeloma (HM) cells. At a relatively high PAF concentration (up to 10(-8) M), the rate of proliferation is significantly decreased, while the IgE secretion rate is increased. At low PAF concentrations (10(-11) M), the HM cell proliferation rate increases, whereas their ability to IgE secretion decreases. The specific secretion activity (per cell) is a linear function in the range of PAF concentrations from 10(-11) to 10(-8) M. This behavior can be used for the quantitative determination of PAF in biological media.

