Related Experiment Video

Updated: Aug 15, 2026

Tracking Drug-induced Changes in Receptor Post-internalization Trafficking by Colocalizational Analysis
07:48

Tracking Drug-induced Changes in Receptor Post-internalization Trafficking by Colocalizational Analysis

Published on: July 3, 2015

[The interaction of mu-opioid receptors with intracellular signal systems]

L N Maslov, Iu B Lishmanov, N V Solenkova

    Eksperimental'Naia I Klinicheskaia Farmakologiia
    |October 1, 2005
    PubMed

    Insights

    This review covers the micro-opioid receptor

    Area of Science:

    • Biochemistry
    • Molecular Biology
    • Neuropharmacology

    Context:

    • The micro-opioid receptor (MOR) is a key player in pain modulation and reward pathways.
    • Understanding MOR signaling is crucial for developing targeted therapeutics.
    • Recent research has elucidated complex interactions beyond traditional G-protein coupling.

    Purpose:

    • To provide a comprehensive overview of the current research landscape concerning the micro-opioid receptor.
    • To detail the molecular integration and signaling pathways associated with MOR.
    • To highlight the receptor's interactions with various enzymes and signaling cascades.

    Summary:

    • This review examines the modern state of micro-opioid receptor (MOR) research.
    • It discusses literature data on MOR integration with adenylyl cyclase, phospholipase A2, C, and D.
    • Reports on MOR interaction with NO-synthase and guanylyl cyclase are analyzed.

    Impact:

    • Provides a consolidated resource for researchers in neuroscience and pharmacology.
    • Identifies potential targets for novel analgesic and addiction treatments.
    • Facilitates a deeper understanding of opioid receptor signaling complexity.

    More Related Videos

    3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache10:39

    3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

    Published on: June 2, 2014

    Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding10:13

    Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding

    Published on: June 9, 2017

    Related Concept Videos

    Opioid Receptors: Overview01:22

    Opioid Receptors: Overview

    Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2, D-Pen5]-enkephalin or DPDPE for...
    Analgesia and Pain Management01:25

    Analgesia and Pain Management

    Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
    Interactions Between Signaling Pathways01:19

    Interactions Between Signaling Pathways

    Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
    Convergence and divergence, and cross-talk between signaling pathways
    Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
    Receptor Downregulation in MVBs01:15

    Receptor Downregulation in MVBs

    Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
    The EGFR can initiate signaling pathways that  lead to cell proliferation, migration, and differentiation. Overexpression of EGFR  stimulates cells to proliferate. Excessive  EGFR activation may...
    Opioid Analgesics: Morphine and Other Natural Cogeners01:20

    Opioid Analgesics: Morphine and Other Natural Cogeners

    Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
    Assembly of Signaling Complexes01:30

    Assembly of Signaling Complexes

    Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
    Interaction domains in cell signaling
    Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...